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KMID : 0358319960370111221
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Korean Journal of Urology
1996 Volume.37 No. 11 p.1221 ~ p.1226
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Prognostic Significance of E-cadherin Expression in Renal Cell Carcinoma
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Abstract
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E-cadherin is one of intercellulaqr adhesion molecules, and it has been demonstrated that E-cadhedrin acts as an invasion suppressor in vitro and loss of its expression is an important prognostic factor in human maljignancies. However the
prognostic
value of loss of expression of E-cadhedrin in renal cell carcinoma (RCC) remains to be defined.
We herein immmunohistochemically examined the dexpression of E-cadhedrin in paraffinembedded tissues of 43 patients with RCC to investigdate the prognostic value of loss of expression of E-cadherin. Twenty three of 43 patients (54.5%) showed loss
of
expression of E-cadherin. There were significant correlations between loss of expression of E-cadherin and histopathologic grade, Robson stage, T stage, N stage and M stage (all p<0.05). Patients with loss of expredssion of E-cadherin shlowed
significantly decreased 2 year disease free survival as compared with those with normal expression of E-cadherin (p<0.001).
These results suggest that loss of expression of E-cadherin has a ominous prognostic value in patients with RCC.
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KEYWORD
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